Groupe Neurotoxicité & Développement-publications

RETOUR AUX EQUIPES

Présentation
Membres
Projets
Publications

Retrouvez ici toutes les publications des membres du groupe:

Cliquez ici

Publications principales

2025

Altered development in rodent brain cells after 900 MHz radiofrequency exposure

Raphaël Bodin, Lucas Godin, Camille Mougin, Anthony Lecomte, Vanessa Larrigaldie, Justyne Feat-Vetel, Sarah Méresse, Céline Montécot-Dubourg, Paulo Marcelo, Stéphane Mortaud, Anne-Sophie VillegierNeurotoxicology 2025 (111)  https://doi.org/10.1016/j.neuro.2025.103312 

Highlights

• In vivo exposure reduced cortex cell proliferation, BDNF and synapses balance.
• In vivo exposure reduced hippocampus synapses density and balance.
• Proteomic analysis showed dysregulation of proteins involved in synaptic signaling.
• In vitro exposure increased apoptosis, DNA damage and glial differentiation shift.
• 900 MHz exposure affect rodent neurodevelopmental at regulatory threshold levels.

2024

Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model.

Bataveljic D, Pivonkova H, de Concini V, Hébert B, Ezan P, Briault S, Bemelmans AP, Pichon J, Menuet A and Rouach NNature communications, 04-2024 https://doi.org/10.1038/s41467-024-47681-y 

2023

The herbicides glyphosate and glufosinate and the cyanotoxin β-N-methylamino-l-alanine induce long-term motor disorders following postnatal exposure: the importance of prior asymptomatic maternal inflammatory sensitization

Asma Oummadi, Arnaud Menuet, Sarah Méresse, Anthony Laugeray, Gilles Guillemin and Stéphane MortaudFront. Neurosci., 09 June 2023 https://doi.org/10.3389/fnins.2023.1172693 

Haslea Ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model

Sarah Méresse, Hélène Gateau, Tessa Tirnan, Vanessa Larrigaldie, Nathalie Casse,Pamela Pasetto, Jean-Luc Mouget, Stéphane Mortaud and Mostefa Fodil Int. J. Mol. Sci. 2023, 24(6), 5388; https://doi.org/10.3390/ijms24065388 
 

2022

β-N-Methyl-Amino-L-Alanine cyanotoxin promotes modification of undifferentiated cells population and disrupts the inflammatory status in primary cultures of neural stem cells.

Méresse S, Larrigaldie V, Oummadi A, de Concini V, Morisset-Lopez S, Reverchon F, Menuet A, Montécot-Dubourg C, Mortaud S.Toxicology. 2022 Dec;482:153358. doi: 10.1016/j.tox.2022.153358. Epub 2022 Oct 27.PMID: 36309149 

When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms.

Vaudin P, Augé C, Just N, Mhaouty-Kodja S, Mortaud S, Pillon D.Environ Res. 2022 Apr 1;205:112495. doi: 10.1016/j.envres.2021.112495. Epub 2021 Dec 6.PMID: 34883077 

2020

3Rs-based optimization of mice behavioral testing: The habituation/dishabituation olfactory test.

Oummadi A, Meyer-Dilhet G, Béry A, Aubert A, Barone P, Mortaud S, Guillemin GJ, Menuet A, Laugeray A.J Neurosci Methods. 2020 Feb 15;332:108550. doi: 10.1016/j.jneumeth.2019.108550. Epub 2019 Dec 12.PMID: 31838181

2019

Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice.

Feat-Vetel J, Larrigaldie V, Meyer-Dilhet G, Herzine A, Mougin C, Laugeray A, Gefflaut T, Richard O, Quesniaux V, Montécot-Dubourg C, Mortaud S.Neurotoxicology. 2018 Dec;69:152-163. doi: 10.1016/j.neuro.2018.10.001. Epub 2018 Oct 10.PMID: 30312642
 

2017

In utero and lactational exposure to low-doses of the pyrethroid insecticide cypermethrin leads to neurodevelopmental defects in male mice-An ethological and transcriptomic study.

Laugeray A, Herzine A, Perche O, Richard O, Montecot-Dubourg C, Menuet A, Mazaud-Guittot S, Lesné L, Jegou B, Mortaud S.PLoS One. 2017 Oct 11;12(10):e0184475. doi: 10.1371/journal.pone.0184475. eCollection 2017.PMID: 29020013 

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria.

Reverchon F, Mortaud S, Sivoyon M, Maillet I, Laugeray A, Palomo J, Montécot C, Herzine A, Meme S, Meme W, Erard F, Ryffel B, Menuet A, Quesniaux VFJ.PLoS Pathog. 2017 Apr 27;13(4):e1006322. doi: 10.1371/journal.ppat.1006322. eCollection 2017 Apr.

PMID: 28448579  

2016

Perinatal Exposure to Glufosinate Ammonium Herbicide Impairs Neurogenesis and Neuroblast Migration through Cytoskeleton Destabilization.

Herzine A, Laugeray A, Feat J, Menuet A, Quesniaux V, Richard O, Pichon J, Montécot-Dubourg C, Perche O, Mortaud S.Front Cell Neurosci. 2016 Aug 9;10:191. doi: 10.3389/fncel.2016.00191. eCollection 2016.PMID: 27555806

Glufosinate aerogenic exposure induces glutamate and IL-1 receptor dependent lung inflammation.

Maillet I, Perche O, Pâris A, Richard O, Gombault A, Herzine A, Pichon J, Huaux F, Mortaud S, Ryffel B, Quesniaux VF, Montécot-Dubourg C.Clin Sci (Lond). 2016 Nov 1;130(21):1939-54. doi: 10.1042/CS20160530. Epub 2016 Aug 22.PMID: 27549113

Characterization of seizures induced by acute exposure to an organophosphate herbicide, glufosinate-ammonium.

Calas AG, Perche O, Richard O, Perche A, Pâris A, Lauga F, Herzine A, Palomo J, Ardourel MY, Menuet A, Mortaud S, Pichon J, Montécot-Dubourg C.Neuroreport. 2016 May 4;27(7):532-41. doi: 10.1097/WNR.0000000000000578.PMID: 27031874

2014

Pre- and postnatal exposure to low dose glufosinate ammonium induces autism-like phenotypes in mice.

Laugeray A, Herzine A, Perche O, Hébert B, Aguillon-Naury M, Richard O, Menuet A, Mazaud-Guittot S, Lesné L, Briault S, Jegou B, Pichon J, Montécot-Dubourg C, Mortaud S.Front Behav Neurosci. 2014 Nov 20;8:390. doi: 10.3389/fnbeh.2014.00390. eCollection 2014.PMID: 25477793 

© INEM-CNRS ORLEANS 2024

INEM