Publications

Publications du laboratoire

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2023

mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus.

Bergant V, Schnepf D, de Andrade Krätzig N, Hubel P, Urban C, Engleitner T, Dijkman R, Ryffel B, Steiger K, Knolle PA, Kochs G, Rad R, Staeheli P, Pichlmair A.Nat Commun. 2023 Aug 15;14(1):4906. doi: 10.1038/s41467-023-40469-6.PMID: 37582777

 

The herbicides glyphosate and glufosinate and the cyanotoxin β-N-methylamino-l-alanine induce long-term motor disorders following postnatal exposure: the importance of prior asymptomatic maternal inflammatory sensitization.

Oummadi A, Menuet A, Méresse S, Laugeray A, Guillemin G, Mortaud S.Front Neurosci. 2023 Jun 9;17:1172693. doi: 10.3389/fnins.2023.1172693. eCollection 2023.PMID: 37360165 

 

XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors.

Bery A, Etienne O, Mouton L, Mokrani S, Granotier-Beckers C, Gauthier LR, Feat-Vetel J, Kortulewski T, Pérès EA, Desmaze C, Lestaveal P, Barroca V, Laugeray A, Boumezbeur F, Abramovski V, Mortaud SMenuet A, Le Bihan D, Villartay JP, Boussin FD.Cell Rep. 2023 Apr 5;42(4):112342. doi: 10.1016/j.celrep.2023.112342. Online ahead of print.PMID: 37027298 

 

Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model.

Méresse S, Gateau H, Tirnan T, Larrigaldie V, Casse N, Pasetto P, Mouget JL, Mortaud S, Fodil M.Int J Mol Sci. 2023 Mar 11;24(6):5388. doi: 10.3390/ijms24065388.PMID: 36982463 

 

S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity.

Silva de Melo BM, Veras FP, Zwicky P, Lima D, Ingelfinger F, Martins TV, da Silva Prado D, Schärli S, Publio G, Hiroki CH, Melo PH, Saraiva A, Norbiato T, Lima L, Ryffel B, Vogl T, Roth J, Waisman A, Nakaya HI, da Silva Souza C, Cunha FQ, Cunha TM, Becher B, Alves-Filho JC.J Invest Dermatol. 2023 Sep;143(9):1678-1688.e8. doi: 10.1016/j.jid.2023.02.026. Epub 2023 Mar 13.PMID: 36921684


Intrahippocampal Inoculation of Aβ1-42 Peptide in Rat as a Model of Alzheimer’s Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells.
 
Aquino R, de Concini V, Dhenain M, Lam S, Gosset D, Baquedano L, Forero MG, Menuet A, Baril P, Pichon C.Cells. 2023 Feb 22;12(5):694. doi: 10.3390/cells12050694.PMID: 36899831

 

Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure. Leinardi R, Pochet A, Uwambayinema F, Yakoub Y, Quesniaux VRyffel B, Broz P, Pavan C, Huaux F.Arch Toxicol. 2023 Apr;97(4):1001-1015. doi: 10.1007/s00204-023-03463-x. Epub 2023 Feb 25.PMID: 36840754 

 

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype. Muela-Zarzuela I, Suarez-Rivero JM, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, Couillin IRyffel B, Kitaura J, Sanz A, von Zglinicki T, Mbalaviele G, Cordero MD.bioRxiv. 2023 Mar 28:2023.02.06.527254. doi: 10.1101/2023.02.06.527254. Preprint.PMID: 36798300

 

2022

Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns. Vasile F, Dossi E, Moulard J, Ezan P, Lecoin L, Cohen-Salmon M, Mailly P, Le Bert MCouillin I, Bemelmans A, Rouach N.PLoS Biol. 2022 Dec 7;20(12):e3001891. doi: 10.1371/journal.pbio.3001891. eCollection 2022 Dec.PMID: 36477165 

 

STING Targeting in Lung Diseases. de Moura Rodrigues D, Lacerda-Queiroz N, Couillin IRiteau N.Cells. 2022 Nov 3;11(21):3483. doi: 10.3390/cells11213483.PMID: 36359882 

 

Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders. Corrêa RO, Castro PR, Moser R, Ferreira CM, Quesniaux VFJ, Vinolo MAR, Ryffel B.Front Nutr. 2022 Oct 20;9:1011732. doi: 10.3389/fnut.2022.1011732. eCollection 2022.PMID: 36337621

 

Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients. Bauer A, Pachl E, Hellmuth JC, Kneidinger N, Heydarian M, Frankenberger M, Stubbe HC, Ryffel B, Petrera A, Hauck SM, Behr J, Kaiser R, Scherer C, Deng L, Teupser D, Ahmidi N, Muenchhoff M, Schubert B, Hilgendorff A.Biochim Biophys Acta Mol Basis Dis. 2023 Feb;1869(2):166592. doi: 10.1016/j.bbadis.2022.166592. Epub 2022 Nov 1.PMID: 36328146

 

β-N-Methyl-Amino-L-Alanine cyanotoxin promotes modification of undifferentiated cells population and disrupts the inflammatory status in primary cultures of neural stem cells. Méresse S, Larrigaldie V, Oummadi A, de Concini V, Morisset-Lopez S, Reverchon F, Menuet AMontécot-Dubourg CMortaud S.Toxicology. 2022 Dec;482:153358. doi: 10.1016/j.tox.2022.153358. Epub 2022 Oct 27.PMID: 36309149

 

T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients. Reverchon F, Guillard C, Mollet L, Auzou P, Gosset D, Madouri F, Valéry A, Menuet A, Ozsancak C, Pallix-Guyot M, Morisset-Lopez S.Biomedicines. 2022 Sep 27;10(10):2418. doi: 10.3390/biomedicines10102418.PMID: 36289679

 

IL-17 and IL-22 are pivotal cytokines to delay wound healing of S. aureus and P. aeruginosa infected skin. Lecron JC, Charreau S, Jégou JF, Salhi N, Petit-Paris I, Guignouard E, Burucoa C, Favot-Laforge L, Bodet C, Barra A, Huguier V, Mcheik J, Dumoutier L, Garnier J, Bernard FX, Ryffel B, Morel F.Front Immunol. 2022 Oct 7;13:984016. doi: 10.3389/fimmu.2022.984016. eCollection 2022.PMID: 36275755

 

Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes. Cordier-Dirikoc S, Pedretti N, Garnier J, Clarhaut-Charreau S, Ryffel B, Morel F, Bernard FX, Hamon de Almeida V, Lecron JC, Jégou JF.Front Immunol. 2022 Oct 3;13:984045. doi: 10.3389/fimmu.2022.984045. eCollection 2022.PMID: 36268013

 

Oral supplementation with selected Lactobacillus acidophilus triggers IL-17-dependent innate defense response, activation of innate lymphoid cells type 3 and improves colitis. Hrdý J, Couturier-Maillard A, Boutillier D, Lapadatescu C, Blanc P, Procházka J, Pot B, Ryffel B, Grangette C, Chamaillard M.Sci Rep. 2022 Oct 20;12(1):17591. doi: 10.1038/s41598-022-21643-0.PMID: 36266398 

 

FMR protein: Evidence of an emerging role in retinal aging? Ardourel M, Ranchon-Cole I, Pâris A, Felgerolle C, Acar N, Lesne F, Briault SPerche O.Exp Eye Res. 2022 Dec;225:109282. doi: 10.1016/j.exer.2022.109282. Epub 2022 Oct 17.PMID: 36265576 

 

FMRP-related retinal phenotypes: Evidence of glutamate-glutamine metabolic cycle impairment. Ardourel M, Pâris A, Felgerolle C, Lesne F, Ranchon-Cole I, Briault SPerche O.Exp Eye Res. 2022 Nov;224:109238. doi: 10.1016/j.exer.2022.109238. Epub 2022 Sep 5.PMID: 36067823 

 

Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3. Huot-Marchand S, Nascimento M, Culerier E, Bourenane M, Savigny F, Panek C, Serdjebi C, Le Bert MQuesniaux VFJRyffel B, Broz P, Riteau NGombault ACouillin I.Front Immunol. 2022 Aug 15;13:918507. doi: 10.3389/fimmu.2022.918507. eCollection 2022.PMID: 36045672

 

A Protective Role of NOD2 on Oxazolone-induced Intestinal Inflammation Through IL-1β-mediated Signalling Pathway. Secher T, Couturier A, Huot L, Bouscayrol H, Grandjean T, Boulard O, Hot D, Ryffel B, Chamaillard M.J Crohns Colitis. 2023 Jan 27;17(1):111-122. doi: 10.1093/ecco-jcc/jjac106.PMID: 35917251

 

Differential Regulation of Allergic Airway Inflammation by Acetylcholine. Roberts LB, Berkachy R, Wane M, Patel DF, Schnoeller C, Lord GM, Gounaris K, Ryffel BQuesniaux V, Darby M, Horsnell WGC, Selkirk ME.Front Immunol. 2022 May 27;13:893844. doi: 10.3389/fimmu.2022.893844. eCollection 2022.PMID: 35711456 

 

Natural history study and statistical modeling of disease progression in a preclinical model of myotubular myopathy. Buono S, Monseur A, Menuet A, Robé A, Koch C, Laporte J, Thielemans L, Depla M, Cowling BS.Dis Model Mech. 2022 Jul 1;15(7):dmm049284. doi: 10.1242/dmm.049284. Epub 2022 Jul 25.PMID: 35642830

 

NLRP6 negatively regulates type 2 immune responses in mice. Chenuet P, Marquant Q, Fauconnier L, Youness A, Mellier M, Marchiol T, Rouxel N, Messaoud-Nacer Y, Maillet I, Ledru A, Quesniaux VFJRyffel B, Horsnell W, Végran F, Apetoh L, Togbe D.Allergy. 2022 Nov;77(11):3320-3336. doi: 10.1111/all.15388. Epub 2022 Jun 10.PMID: 35615773

 

Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors. El Khamlichi C, Reverchon F, Hervouet-Coste N, Robin E, Chopin N, Deau E, Madouri F, Guimpied C, Colas C, Menuet A, Inoue A, Bojarski AJ, Guillaumet G, Suzenet F, Reiter E, Morisset-Lopez S.Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2118847119. doi: 10.1073/pnas.2118847119. Epub 2022 May 20.PMID: 35594393

 

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors. Galli G, Vacher P, Ryffel B, Blanco P, Legembre P.Cells. 2022 Apr 24;11(9):1438. doi: 10.3390/cells11091438.PMID: 35563744

 

Sensitivity and specificity of heat and moisture exchange filters sampling for SARS-CoV-2 detection in mechanically ventilated COVID-19 patients. Kamel T, Guillaume C, Muller G, Baala L, Boulain T.J Microbiol Immunol Infect. 2022 Dec;55(6 Pt 1):1122-1125. doi: 10.1016/j.jmii.2022.04.002. Epub 2022 Apr 14.PMID: 35534384

 

Large-conductance calcium-activated potassium channel haploinsufficiency leads to sensory deficits in the visual system: a case report. Perche O, Lesne F, Patat A, Raab S, Twyman R, Ring RH, Briault S.J Med Case Rep. 2022 May 5;16(1):180. doi: 10.1186/s13256-022-03387-7.PMID: 35509069 

 

Targeted autophagy disruption reveals the central role of macrophage iron metabolism in systemic iron homeostasis. Taleb M, Maillet I, Le Bert MMura C.Blood. 2022 Jul 28;140(4):374-387. doi: 10.1182/blood.2021014493.PMID: 35472080 

 

Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway. Lima C, Andrade-Barros AI, Bernardo JTG, Balogh E, Quesniaux VFRyffel B, Lopes-Ferreira M.Int J Mol Sci. 2022 Mar 25;23(7):3600. doi: 10.3390/ijms23073600.PMID: 35408954


Deletion of Mocos Induces Xanthinuria with Obstructive Nephropathy and Major Metabolic Disorders in Mice.
Sedda D, Mackowiak C, Pailloux J, Culerier E, Dudas A, Rontani P, Erard N, Lefevre A, Mavel S, Emond P, Foucher F, Le Bert MQuesniaux VFJ, Mihatsch MJ, Ryffel B, Erard-Garcia M.Kidney360. 2021 Sep 17;2(11):1793-1806. doi: 10.34067/KID.0001732021. eCollection 2021 Nov 25.PMID: 35372998 

 

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS). Messaoud-Nacer Y, Culerier E, Rose S, Maillet I, Rouxel N, Briault SRyffel BQuesniaux VFJTogbe D.Cell Death Dis. 2022 Mar 25;13(3):269. doi: 10.1038/s41419-022-04664-5.PMID: 35338116 

 

Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses. Bruchard M, Geindreau M, Perrichet A, Truntzer C, Ballot E, Boidot R, Racoeur C, Barsac E, Chalmin F, Hibos C, Baranek T, Paget C, Ryffel B, Rébé C, Paul C, Végran F, Ghiringhelli F.Nat Immunol. 2022 Feb;23(2):262-274. doi: 10.1038/s41590-021-01120-y. Epub 2022 Jan 31.PMID: 35102345

 

The osteoprotective role of USP26 in coordinating bone formation and resorption. Li C, Qiu M, Chang L, Qi J, Zhang L, Ryffel B, Deng L.Cell Death Differ. 2022 Jun;29(6):1123-1136. doi: 10.1038/s41418-021-00904-x. Epub 2022 Jan 29.PMID: 35091692 

 

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells. Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Melis A, Vinokurova D, Shahoei SH, Baeza Garcia A, Pignol C, Giorgiutti S, Carapito R, Boidot R, Végran F, Flavell RA, Ryffel B, Nelson ER, Soulas-Sprauel P, Lawrence T, Apetoh L.J Immunother Cancer. 2022 Jan;10(1):e003459. doi: 10.1136/jitc-2021-003459.PMID: 35091453 

 

The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses. Jacques C, Chatelais M, Fekir K, Fauconnier L, Mellier M, Togbe D, Floris I.Int J Mol Sci. 2021 Dec 22;23(1):110. doi: 10.3390/ijms23010110.PMID: 35008536

 

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis. Yonekura S, Terrisse S, Alves Costa Silva C, Lafarge A, Iebba V, Ferrere G, Goubet AG, Fahrner JE, Lahmar I, Ueda K, Mansouri G, Pizzato E, Ly P, Mazzenga M, Thelemaque C, Fidelle M, Jaulin F, Cartry J, Deloger M, Aglave M, Droin N, Opolon P, Puget A, Mann F, Neunlist M, Bessard A, Aymeric L, Matysiak-Budnik T, Bosq J, Hofman P, Duong CPM, Ugolini S, Quiniou V, Berrard S, Ryffel B, Kepp O, Kroemer G, Routy B, Lordello L, Bani MA, Segata N, Yengej FY, Clevers H, Scoazec JY, Pasolli E, Derosa L, Zitvogel L.Cancer Discov. 2022 Apr 1;12(4):1128-1151. doi: 10.1158/2159-8290.CD-21-0999.PMID: 34930787

 

When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms. Vaudin P, Augé C, Just N, Mhaouty-Kodja S, Mortaud S, Pillon D.Environ Res. 2022 Apr 1;205:112495. doi: 10.1016/j.envres.2021.112495. Epub 2021 Dec 6.PMID: 34883077 

2021

Segueni, N., M. Jacobs, and B. Ryffel. 2021.

Innate type 1 immune response, but not IL-17 cells control tuberculosis infectionBiomed J

 

Rontani, P., O. Perche, L. Greetham, N. Jullien, B. Gepner, F. Féron, E. Nivet, and M. Erard-Garcia. 2021.

Impaired expression of the COSMOC/MOCOS gene unit in ASD patient stem cellsMolecular psychiatry

 

Mackowiak, C., T. Marchiol, H. C. Paljetak, L. Fauconnier, J. Palomo, T. Secher, C. Panek, D. Sedda, F. Savigny, F. Erard, A. Bragonzi, F. Huaux, T. Stoeger, H. B. Schiller, J. C. Sirard, M. Le Bert, I. Couillin, V. F. J. Quesniaux, D. Togbe, and B. Ryffel. 2021.

Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 SignalingImmunohorizons

 

Chung, K. F., D. Togbe, and B. Ryffel. 2021.

Editorial: Ozone as a Driver of Lung Inflammation and Innate Immunity and as a Model for Lung DiseaseFront Immunol

 

Alves-Filho, J. C., B. Marcel Silva Melo, and B. Ryffel. 2021.

MMP-9 Mediates Cross-Talk between Neutrophils and Endothelial Cells in PsoriasisJ Invest Dermatol

2020

Wollin, L., D. Togbe, and B. Ryffel. 2020.

Effects of Nintedanib in an Animal Model of Liver FibrosisBiomed Res Int

 

Togbe, D., S. Benmerzoug, M. Jacobs, B. Ryffel, and V. F. J. Quesniaux. 2020.

Silica-related diseases in the modern world: A role for self-DNA sensing in lung inflammatory diseasesAllergy

 

Savigny, F., C. Schricke, N. Lacerda-Queiroz, M. Meda, M. Nascimento, S. Huot-Marchand, F. Da Gama Monteiro, B. Ryffel, A. Gombault, M. Le Bert, I. Couillin, and N. Riteau. 2020.

Protective Role of the Nucleic Acid Sensor STING in Pulmonary FibrosisFront Immunol

 

Reverchon, F., V. de Concini, V. Larrigaldie, S. Benmerzoug, S. Briault, D. Togbé, B. Ryffel, V. F. J. Quesniaux, and A. Menuet. 2020.

Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairmentsJ Neuroinflammation

 

Nascimento, M., S. Huot-Marchand, A. Gombault, C. Panek, M. Bourinet, M. Fanny, F. Savigny, P. Schneider, M. Le Bert, B. Ryffel, N. Riteau, V. F. J. Quesniaux, and I. Couillin. 2020.

B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke ExposureFront Immunol

 

Michaudel, C., F. Bataille, I. Maillet, L. Fauconnier, C. Colas, H. Sokol, M. Straube, A. Couturier-Maillard, L. Dumoutier, J. van Snick, V. F. Quesniaux, D. Togbe, and B. Ryffel. 2020.

Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 ModulationFront Immunol

2019

Sokolowska, M., V. F. J. Quesniaux, C. A. Akdis, K. F. Chung, B. Ryffel, and D. Togbe. 2019.

Acute Respiratory Barrier Disruption by Ozone Exposure in MiceFront Immunol

 

Nascimento, M., A. Gombault, N. Lacerda-Queiroz, C. Panek, F. Savigny, M. Sbeity, M. Bourinet, M. Le Bert, N. Riteau, B. Ryffel, V. F. J. Quesniaux, and I. Couillin. 2019.

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in miceSci Rep

 

Felgerolle, C., B. Hébert, M. Ardourel, G. Meyer-Dilhet, A. Menuet, K. Pinto-Morais, J. C. Bizot, J. Pichon, S. Briault, and O. Perche. 2019.

Visual Behavior Impairments as an Aberrant Sensory Processing in the Mouse Model of Fragile X SyndromeFrontiers in behavioral neuroscience

 

Couturier-Maillard, A., N. Froux, J. Piotet-Morin, C. Michaudel, L. Brault, J. Le Bérichel, A. Sénéchal, P. Robinet, P. Chenuet, S. Jejou, L. Dumoutier, J. C. Renauld, J. Iovanna, S. Huber, M. Chamaillard, V. F. J. Quesniaux, H. Sokol, and B. Ryffel. 2019.

Correction: Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammationMucosal Immunol

 

Benmerzoug, S., B. Ryffel, D. Togbe, and V. F. J. Quesniaux. 2019.

Self-DNA Sensing in Lung Inflammatory DiseasesTrends Immunol

 

Benmerzoug, S., B. Bounab, S. Rose, D. Gosset, F. Biet, T. Cochard, A. Xavier, N. Rouxel, L. Fauconnier, W. G. C. Horsnell, B. Ryffel, D. Togbe, and V. F. J. Quesniaux. 2019.

Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 ImmunityCell Rep

 

Agoro, R., and C. Mura. 2019. 

Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections? Pharmaceuticals (Basel, Switzerland)

2018 - 2001

Tan, Z., Q. Liu, R. Jiang, L. Lv, S. S. Shoto, I. Maillet, V. Quesniaux, J. Tang, W. Zhang, B. Sun, and B. Ryffel. 2018.

Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells. Cell Mol Immunol

 

Stanek, K. A., and C. Mura. 2018.

Producing Hfq/Sm Proteins and sRNAs for Structural and Biophysical Studies of Ribonucleoprotein Assembly. Methods Mol Biol

 

Secher, T., I. Maillet, C. Mackowiak, J. Le Bérichel, A. Philippeau, C. Panek, M. Boury, E. Oswald, A. Saoudi, F. Erard, M. Le Bert, V. Quesniaux, A. Couturier-Maillard, and B. Ryffel. 2018.

The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice. Sci Rep

 

Perche, O., C. Felgerolle, M. Ardourel, A. Bazinet, A. Pâris, R. Rossignol, G. Meyer-Dilhet, A. L. Mausset-Bonnefont, B. Hébert, D. Laurenceau, C. Montécot-Dubourg, A. Menuet, J. C. Bizot, J. Pichon, I. Ranchon-Cole, and S. Briault. 2018.

Early Retinal Defects in Fmr1(-/y) Mice: Toward a Critical Role of Visual Dys-Sensitivity in the Fragile X Syndrome Phenotype? Frontiers in cellular neuroscience

 

Palomo, J., V. F. J. Quesniaux, D. Togbe, F. Reverchon, and B. Ryffel. 2018.

Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis. Parasite Immunol

 

Michaudel, C., I. Maillet, L. Fauconnier, V. Quesniaux, K. F. Chung, C. Wiegman, D. Peter, and B. Ryffel. 2018.

Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation. Front Immunol

 

Michaudel, C., C. Mackowiak, I. Maillet, L. Fauconnier, C. A. Akdis, M. Sokolowska, A. Dreher, H. T. Tan, V. F. Quesniaux, B. Ryffel, and D. Togbe. 2018.

Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33. J Allergy Clin Immunol

 

Michaudel, C., L. Fauconnier, Y. Julé, and B. Ryffel. 2018.

Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice. Sci Rep

 

Marinho, F. V., S. Benmerzoug, S. Rose, P. C. Campos, J. T. Marques, A. Báfica, G. Barber, B. Ryffel, S. C. Oliveira, and V. F. J. Quesniaux. 2018.

The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection. J Innate Immun

 

Feat-Vetel, J., V. Larrigaldie, G. Meyer-Dilhet, A. Herzine, C. Mougin, A. Laugeray, T. Gefflaut, O. Richard, V. Quesniaux, C. Montécot-Dubourg, and S. Mortaud. 2018.

Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology

 

Fanny, M., M. Nascimento, L. Baron, C. Schricke, I. Maillet, M. Akbal, N. Riteau, M. Le Bert, V. Quesniaux, B. Ryffel, A. Gombault, S. Même, W. Même, and I. Couillin. 2018.

The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin. Front Immunol

 

Di Padova, F., V. F. J. Quesniaux, and B. Ryffel. 2018.

MyD88 as a therapeutic target for inflammatory lung diseases. Expert Opin Ther Targets

 

Couturier-Maillard, A., N. Froux, J. Piotet-Morin, C. Michaudel, L. Brault, J. Le Bérichel, A. Sénéchal, P. Robinet, P. Chenuet, S. Jejou, L. Dumoutier, J. C. Renauld, J. Iovanna, S. Huber, M. Chamaillard, V. Quesniaux, H. Sokol, M. Chamaillard, and B. Ryffel. 2018.

Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation. Mucosal Immunol

 

Cordero, M. D., M. R. Williams, and B. Ryffel. 2018.

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging. Trends Endocrinol Metab

 

Cordero, M. D., E. Alcocer-Gómez, and B. Ryffel. 2018.

Gain of function mutation and inflammasome driven diseases in human and mouse models. J Autoimmun

 

Benmerzoug, S., S. Rose, B. Bounab, D. Gosset, L. Duneau, P. Chenuet, L. Mollet, M. Le Bert, C. Lambers, S. Geleff, M. Roth, L. Fauconnier, D. Sedda, C. Carvalho, O. Perche, D. Laurenceau, B. Ryffel, L. Apetoh, A. Kiziltunc, H. Uslu, F. S. Albez, M. Akgun, D. Togbe, and V. F. J. Quesniaux. 2018.

STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nat Commun

 

Benmerzoug, S., F. V. Marinho, S. Rose, C. Mackowiak, D. Gosset, D. Sedda, E. Poisson, C. Uyttenhove, J. Van Snick, M. Jacobs, I. Garcia, B. Ryffel, and V. F. J. Quesniaux. 2018.

GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection. Sci Rep

 

Agoro, R., M. Taleb, V. F. J. Quesniaux, and C. Mura. 2018.

Cell iron status influences macrophage polarization. PLoS One

 

Stanek, K. A., J. Patterson-West, P. S. Randolph, and C. Mura. 2017.

Crystal structure and RNA-binding properties of an Hfq homolog from the deep-branching Aquificae: conservation of the lateral RNA-binding mode. Acta crystallographica. Section D, Structural biology

 

Reverchon, F., S. Mortaud, M. Sivoyon, I. Maillet, A. Laugeray, J. Palomo, C. Montécot, A. Herzine, S. Meme, W. Meme, F. Erard, B. Ryffel, A. Menuet, and V. F. J. Quesniaux. 2017.

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria. PLoS Pathog

 

Marinho, F. V., S. Benmerzoug, S. C. Oliveira, B. Ryffel, and V. F. J. Quesniaux. 2017.

The Emerging Roles of STING in Bacterial Infections. Trends Microbiol

 

Madouri, F., P. Chenuet, C. Beuraud, L. Fauconnier, T. Marchiol, N. Rouxel, A. Ledru, M. Gallerand, V. Lombardi, L. Mascarell, Q. Marquant, L. Apetoh, F. Erard, M. Le Bert, F. Trovero, V. F. J. Quesniaux, B. Ryffel, and D. Togbe. 2017.

Protein kinase Cθ controls type 2 innate lymphoid cell and T(H)2 responses to house dust mite allergen. J Allergy Clin Immunol

 

Li, C., I. Maillet, C. Mackowiak, C. Viala, F. Di Padova, M. Li, D. Togbe, V. Quesniaux, Y. Lai, and B. Ryffel. 2017.

Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells. Cell Death Dis

 

Laugeray, A., A. Herzine, O. Perche, O. Richard, C. Montecot-Dubourg, A. Menuet, S. Mazaud-Guittot, L. Lesné, B. Jegou, and S. Mortaud. 2017.

In utero and lactational exposure to low-doses of the pyrethroid insecticide cypermethrin leads to neurodevelopmental defects in male mice-An ethological and transcriptomic study. PLoS One

 

Chenuet, P., L. Fauconnier, F. Madouri, T. Marchiol, N. Rouxel, A. Ledru, P. Mauny, R. Lory, C. Uttenhove, J. van Snick, Y. Iwakura, F. di Padova, V. Quesniaux, D. Togbe, and B. Ryffel. 2017.

Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice. Clin Sci (Lond)

 

Benmerzoug, S., and V. F. J. Quesniaux. 2017.

Bioengineered 3D Models for Studying Human Cell-Tuberculosis Interactions. Trends Microbiol

 

Agoro, R., S. Benmerzoug, S. Rose, M. Bouyer, R. Gozzelino, I. Garcia, B. Ryffel, V. F. J. Quesniaux, and C. Mura. 2017.

An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection. J Infect Dis

 

Segueni, N., E. Tritto, M. L. Bourigault, S. Rose, F. Erard, M. Le Bert, M. Jacobs, F. Di Padova, D. P. Stiehl, P. Moulin, D. Brees, S. D. Chibout, B. Ryffel, M. Kammüller, and V. F. Quesniaux. 2016.

Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization. Sci Rep

 

Segueni, N., S. Benmerzoug, S. Rose, A. Gauthier, M. L. Bourigault, F. Reverchon, A. Philippeau, F. Erard, M. Le Bert, H. Bouscayrol, T. Wachter, I. Garcia, G. Kollias, M. Jacobs, B. Ryffel, and V. F. Quesniaux. 2016.

Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection. Sci Rep

 

Riteau, N., A. Gombault, and I. Couillin. 2016.

Assessment of Inflammasome Activation by Cytokine and Danger Signal Detection. Methods Mol Biol

 

Michaudel, C., A. Couturier-Maillard, P. Chenuet, I. Maillet, C. Mura, I. Couillin, A. Gombault, V. F. Quesniaux, F. Huaux, and B. Ryffel. 2016.

Inflammasome, IL-1 and inflammation in ozone-induced lung injury. Am J Clin Exp Immunol

 

McAnany, C. E., and C. Mura. 2016.

Claws, Disorder, and Conformational Dynamics of the C-Terminal Region of Human Desmoplakin. The journal of physical chemistry. B

 

Laudier, B., T. Epiais, A. Pâris, A. Menuet, S. Briault, C. Ozsancak, and O. Perche. 2016.

Molecular and clinical analyses with neuropsychological assessment of a case of del(10)(q26.2qter) without intellectual disability: Genomic and transcriptomic combined approach and review of the literature. American journal of medical genetics. Part A

 

Herzine, A., A. Laugeray, J. Feat, A. Menuet, V. Quesniaux, O. Richard, J. Pichon, C. Montécot-Dubourg, O. Perche, and S. Mortaud. 2016.

Perinatal Exposure to Glufosinate Ammonium Herbicide Impairs Neurogenesis and Neuroblast Migration through Cytoskeleton Destabilization. Frontiers in cellular neuroscience

 

Féron, F., B. Gepner, E. Lacassagne, D. Stephan, B. Mesnage, M. P. Blanchard, N. Boulanger, C. Tardif, A. Devèze, S. Rousseau, K. Suzuki, J. C. Izpisua Belmonte, M. Khrestchatisky, E. Nivet, and M. Erard-Garcia. 2016.

Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. Molecular psychiatry

 

Ekmekci, B., C. E. McAnany, and C. Mura. 2016.

An Introduction to Programming for Bioscientists: A Python-Based Primer. PLoS computational biology

 

Agoro, R., and C. Mura. 2016.

Inflammation-induced up-regulation of hepcidin and down-regulation of ferroportin transcription are dependent on macrophage polarization. Blood cells, molecules & diseases

 

Palomo, J., F. Reverchon, J. Piotet, A. G. Besnard, A. Couturier-Maillard, I. Maillet, M. Tefit, F. Erard, D. Mazier, B. Ryffel, and V. F. Quesniaux. 2015.

Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. Eur J Immunol

 

Madouri, F., N. Guillou, L. Fauconnier, T. Marchiol, N. Rouxel, P. Chenuet, A. Ledru, L. Apetoh, F. Ghiringhelli, M. Chamaillard, S. G. Zheng, F. Trovero, V. F. Quesniaux, B. Ryffel, and D. Togbe. 2015.

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation. J Mol Cell Biol

 

Gray, C., C. W. Price, C. T. Lee, A. H. Dewald, M. A. Cline, C. E. McAnany, L. Columbus, and C. Mura. 2015.

Known structure, unknown function: An inquiry-based undergraduate biochemistry laboratory course. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

 

François, A., A. Gombault, B. Villeret, G. Alsaleh, M. Fanny, P. Gasse, S. M. Adam, B. Crestani, J. Sibilia, P. Schneider, S. Bahram, V. Quesniaux, B. Ryffel, D. Wachsmann, J. E. Gottenberg, and I. Couillin. 2015.

B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis. J Autoimmun

 

Baron, L., A. Gombault, M. Fanny, B. Villeret, F. Savigny, N. Guillou, C. Panek, M. Le Bert, V. Lagente, F. Rassendren, N. Riteau, and I. Couillin. 2015.

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis

 

Wollin, L., I. Maillet, V. Quesniaux, A. Holweg, and B. Ryffel. 2014.

Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther

 

Rossignol, R., I. Ranchon-Cole, A. Pâris, A. Herzine, A. Perche, D. Laurenceau, P. Bertrand, C. Cercy, J. Pichon, S. Mortaud, S. Briault, A. Menuet, and O. Perche. 2014.

Visual sensorial impairments in neurodevelopmental disorders: evidence for a retinal phenotype in Fragile X Syndrome. PLoS One

 

Palomo, J., T. Marchiol, J. Piotet, L. Fauconnier, M. Robinet, F. Reverchon, M. Le Bert, D. Togbe, R. Buijs-Offerman, M. Stolarczyk, V. F. Quesniaux, B. J. Scholte, and B. Ryffel. 2014.

Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection. PLoS One

 

Laugeray, A., A. Herzine, O. Perche, B. Hébert, M. Aguillon-Naury, O. Richard, A. Menuet, S. Mazaud-Guittot, L. Lesné, S. Briault, B. Jegou, J. Pichon, C. Montécot-Dubourg, and S. Mortaud. 2014.

Pre- and postnatal exposure to low dose glufosinate ammonium induces autism-like phenotypes in mice. Frontiers in behavioral neuroscience

 

Hébert, B., S. Pietropaolo, S. Même, B. Laudier, A. Laugeray, N. Doisne, A. Quartier, S. Lefeuvre, L. Got, D. Cahard, F. Laumonnier, W. E. Crusio, J. Pichon, A. Menuet, O. Perche, and S. Briault. 2014.

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule. Orphanet journal of rare diseases

 

Guabiraba, R., and B. Ryffel. 2014.

Dengue virus infection: current concepts in immune mechanisms and lessons from murine models. Immunology

 

Villeret, B., L. Brault, A. Couturier-Maillard, P. Robinet, V. Vasseur, T. Secher, I. Dimier-Poisson, M. Jacobs, S. G. Zheng, V. F. Quesniaux, and B. Ryffel. 2013.

Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice. Am J Clin Exp Immunol

 

Togbe, D., L. Fauconnier, F. Madouri, T. Marchiol, P. Chenuet, N. Rouxel, A. Ledru, F. Erard, V. Quesniaux, and B. Ryffel. 2013.

Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation. ISRN Allergy

 

Tan, Z., R. Jiang, X. Wang, Y. Wang, L. Lu, Q. Liu, S. G. Zheng, B. Sun, and B. Ryffel. 2013.

RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury. J Mol Cell Biol

 

Sedhom, M. A., M. Pichery, J. R. Murdoch, B. Foligné, N. Ortega, S. Normand, K. Mertz, D. Sanmugalingam, L. Brault, T. Grandjean, E. Lefrancais, P. G. Fallon, V. Quesniaux, L. Peyrin-Biroulet, G. Cathomas, T. Junt, M. Chamaillard, J. P. Girard, and B. Ryffel. 2013.

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut

 

Perche, O., A. Menuet, M. Marcos, L. Liu, A. Pâris, K. H. Utami, D. Kervran, V. Cacheux, B. Laudier, and S. Briault. 2013.

Combined deletion of two Condensin II system genes (NCAPG2 and MCPH1) in a case of severe microcephaly and mental deficiency. European journal of medical genetics

 

Patterson, J., and C. Mura. 2013.

Rapid colorimetric assays to qualitatively distinguish RNA and DNA in biomolecular samples. Journal of visualized experiments : JoVE

 

Palomo, J., M. Fauconnier, L. Coquard, M. Gilles, S. Meme, F. Szeremeta, L. Fick, J. F. Franetich, M. Jacobs, D. Togbe, J. C. Beloeil, D. Mazier, B. Ryffel, and V. F. Quesniaux. 2013.

Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol

 

Bourigault, M. L., N. Segueni, S. Rose, N. Court, R. Vacher, V. Vasseur, F. Erard, M. Le Bert, I. Garcia, Y. Iwakura, M. Jacobs, B. Ryffel, and V. F. Quesniaux. 2013.

Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG. Immun Inflamm Dis

 

Besnard, A. G., S. Struyf, R. Guabiraba, L. Fauconnier, N. Rouxel, P. Proost, C. Uyttenhove, J. Van Snick, I. Couillin, and B. Ryffel. 2013.

CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. J Leukoc Biol

 

Riteau, N., L. Baron, B. Villeret, N. Guillou, F. Savigny, B. Ryffel, F. Rassendren, M. Le Bert, A. Gombault, and I. Couillin. 2012.

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation. Cell Death Dis

 

Perche, O., B. Laudier, A. Menuet, S. Odent, F. Laumonnier, and S. Briault. 2012.

FG syndrome: the FGS2 locus revisited. American journal of medical genetics. Part A

 

Gombault, A., L. Baron, and I. Couillin. 2012.

ATP release and purinergic signaling in NLRP3 inflammasome activation. Front Immunol

 

Fauconnier, M., J. Palomo, M. L. Bourigault, S. Meme, F. Szeremeta, J. C. Beloeil, A. Danneels, S. Charron, P. Rihet, B. Ryffel, and V. F. Quesniaux. 2012.

IL-12Rβ2 is essential for the development of experimental cerebral malaria. J Immunol

 

Besnard, A. G., D. Togbe, I. Couillin, Z. Tan, S. G. Zheng, F. Erard, M. Le Bert, V. Quesniaux, and B. Ryffel. 2012.

Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol

 

Yang, Y., C. Férec, and C. Mura. 2011.

SNP and haplotype analysis reveals new HFE variants associated with iron overload trait. Human mutation

 

Maillet, I., S. Schnyder-Candrian, I. Couillin, V. F. Quesniaux, F. Erard, R. Moser, S. Fleury, A. Kanda, D. Dombrowicz, D. E. Szymkowski, and B. Ryffel. 2011.

Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics. Am J Respir Cell Mol Biol

 

Gasse, P., N. Riteau, R. Vacher, M. L. Michel, A. Fautrel, F. di Padova, L. Fick, S. Charron, V. Lagente, G. Eberl, M. Le Bert, V. F. Quesniaux, F. Huaux, M. Leite-de-Moraes, B. Ryffel, and I. Couillin. 2011.

IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PLoS One

 

Garcia, I., M. L. Olleros, V. F. Quesniaux, M. Jacobs, N. Allie, S. A. Nedospasov, D. E. Szymkowski, and B. Ryffel. 2011.

Roles of soluble and membrane TNF and related ligands in mycobacterial infections: effects of selective and non-selective TNF inhibitors during infection. Adv Exp Med Biol

 

Fauconnier, M., M. L. Bourigault, S. Meme, F. Szeremeta, J. Palomo, A. Danneels, S. Charron, L. Fick, M. Jacobs, J. C. Beloeil, B. Ryffel, and V. F. Quesniaux. 2011.

Protein kinase C-theta is required for development of experimental cerebral malaria. Am J Pathol

 

Court, N., S. Rose, M. L. Bourigault, S. Front, O. R. Martin, J. K. Dowling, E. F. Kenny, L. O’Neill, F. Erard, and V. F. Quesniaux. 2011.

Mycobacterial PIMs inhibit host inflammatory responses through CD14-dependent and CD14-independent mechanisms. PLoS One

 

Cieślik, M., and C. Mura. 2011.

A lightweight, flow-based toolkit for parallel and distributed bioinformatics pipelines. BMC bioinformatics

 

Cieślik, M., Z. S. Derewenda, and C. Mura. 2011.

Abstractions, algorithms and data structures for structural bioinformatics in PyCogent. Journal of applied crystallography

 

Besnard, A. G., D. Togbe, N. Guillou, F. Erard, V. Quesniaux, and B. Ryffel. 2011.

IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol

 

Besnard, A. G., R. Sabat, L. Dumoutier, J. C. Renauld, M. Willart, B. Lambrecht, M. M. Teixeira, S. Charron, L. Fick, F. Erard, K. Warszawska, K. Wolk, V. Quesniaux, B. Ryffel, and D. Togbe. 2011.

Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Am J Respir Crit Care Med

 

Besnard, A. G., N. Guillou, J. Tschopp, F. Erard, I. Couillin, Y. Iwakura, V. Quesniaux, B. Ryffel, and D. Togbe. 2011.

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant. Allergy

 

Soares, A. L., F. R. Coelho, R. Guabiraba, M. Kamal, B. B. Vargaftig, L. Li, J. Li, W. Tavares-de-Lima, and B. Ryffel. 2010.

Tumor necrosis factor is not associated with intestinal ischemia/reperfusion-induced lung inflammation. Shock

 

Riteau, N., P. Gasse, L. Fauconnier, A. Gombault, M. Couegnat, L. Fick, J. Kanellopoulos, V. F. Quesniaux, S. Marchand-Adam, B. Crestani, B. Ryffel, and I. Couillin. 2010.

Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med

 

Quesniaux, V. F., M. Jacobs, N. Allie, S. Grivennikov, S. A. Nedospasov, I. Garcia, M. L. Olleros, Y. Shebzukhov, D. Kuprash, V. Vasseur, S. Rose, N. Court, R. Vacher, and B. Ryffel. 2010.

TNF in host resistance to tuberculosis infection. Curr Dir Autoimmun

 

Quesniaux, V., F. Erard, and B. Ryffel. 2010.

Adjuvant activity on murine and human macrophages. Methods Mol Biol

 

Perche, O., F. Laumonnier, L. Baala, M. Y. Ardourel, A. Menuet, V. Robin, S. Mortaud, C. Montécot-Dubourg, O. Richard, J. Pichon, and S. Briault. 2010.

[Autism, genetics and synaptic function alterations]. Pathologie-biologie

 

Jacolot, S., Y. Yang, P. Paitry, C. Férec, and C. Mura. 2010.

Iron metabolism in macrophages from HFE hemochromatosis patients. Molecular genetics and metabolism

 

Court, N., V. Vasseur, R. Vacher, C. Frémond, Y. Shebzukhov, V. V. Yeremeev, I. Maillet, S. A. Nedospasov, S. Gordon, P. G. Fallon, H. Suzuki, B. Ryffel, and V. F. Quesniaux. 2010.

Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol

 

Secher, T., V. Vasseur, D. M. Poisson, J. A. Mitchell, F. Q. Cunha, J. C. Alves-Filho, and B. Ryffel. 2009.

Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. J Immunol

 

Gasse, P., N. Riteau, S. Charron, S. Girre, L. Fick, V. Pétrilli, J. Tschopp, V. Lagente, V. F. Quesniaux, B. Ryffel, and I. Couillin. 2009.

Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med

 

Freitas, A., J. C. Alves-Filho, T. Victoni, T. Secher, H. P. Lemos, F. Sônego, F. Q. Cunha, and B. Ryffel. 2009.

IL-17 receptor signaling is required to control polymicrobial sepsis. J Immunol

 

Doz, E., S. Rose, N. Court, S. Front, V. Vasseur, S. Charron, M. Gilleron, G. Puzo, I. Fremaux, Y. Delneste, F. Erard, B. Ryffel, O. R. Martin, and V. F. Quesniaux. 2009.

Mycobacterial phosphatidylinositol mannosides negatively regulate host Toll-like receptor 4, MyD88-dependent proinflammatory cytokines, and TRIF-dependent co-stimulatory molecule expression. J Biol Chem

 

Daoud, H., N. Gruchy, J. M. Constans, E. Moussaoui, S. Saumureau, N. Bayou, M. Amy, S. Védrine, P. Y. Vu, A. Rötig, F. Laumonnier, P. Vourc’h, C. R. Andres, N. Leporrier, and S. Briault. 2009.

Haploinsufficiency of the GPD2 gene in a patient with nonsyndromic mental retardation. Human genetics

 

Daoud, H., F. Bonnet-Brilhault, S. Védrine, M. V. Demattéi, P. Vourc’h, N. Bayou, C. R. Andres, C. Barthélémy, F. Laumonnier, and S. Briault. 2009.

Autism and nonsyndromic mental retardation associated with a de novo mutation in the NLGN4X gene promoter causing an increased expression level. Biological psychiatry

 

Couillin, I., V. Vasseur, S. Charron, P. Gasse, M. Tavernier, J. Guillet, V. Lagente, L. Fick, M. Jacobs, F. R. Coelho, R. Moser, and B. Ryffel. 2009.

IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J Immunol

 

Carlos, D., C. Fremond, A. Samarina, V. Vasseur, I. Maillet, S. G. Ramos, F. Erard, V. Quesniaux, H. Ohtsu, C. L. Silva, L. H. Faccioli, and B. Ryffel. 2009.

Histamine plays an essential regulatory role in lung inflammation and protective immunity in the acute phase of Mycobacterium tuberculosis infection. Infect Immun

 

Togbe, D., P. L. de Sousa, M. Fauconnier, V. Boissay, L. Fick, S. Scheu, K. Pfeffer, R. Menard, G. E. Grau, B. T. Doan, J. C. Beloeil, L. Renia, A. M. Hansen, H. J. Ball, N. H. Hunt, B. Ryffel, and V. F. Quesniaux. 2008.

Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One

 

Jacolot, S., C. Férec, and C. Mura. 2008.

Iron responses in hepatic, intestinal and macrophage/monocyte cell lines under different culture conditions. Blood cells, molecules & diseases

 

Erard, F., and B. Ryffel. 2008.

Toll like receptor – potential drug targets in infectious disease. Infect Disord Drug Targets

 

Doz, E., N. Noulin, E. Boichot, I. Guénon, L. Fick, M. Le Bert, V. Lagente, B. Ryffel, B. Schnyder, V. F. Quesniaux, and I. Couillin. 2008.

Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol

 

Togbe, D., L. Schofield, G. E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler, V. F. Quesniaux, and B. Ryffel. 2007.

Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol

 

Jacobs, M., D. Togbe, C. Fremond, A. Samarina, N. Allie, T. Botha, D. Carlos, S. K. Parida, S. Grivennikov, S. Nedospasov, A. Monteiro, M. Le Bert, V. Quesniaux, and B. Ryffel. 2007.

Tumor necrosis factor is critical to control tuberculosis infection. Microbes Infect

 

Jacobs, M., A. Samarina, S. Grivennikov, T. Botha, N. Allie, C. Fremond, D. Togbe, V. Vasseur, S. Rose, F. Erard, A. Monteiro, V. Quesniaux, and B. Ryffel. 2007.

Reactivation of tuberculosis by tumor necrosis factor neutralization. Eur Cytokine Netw

 

Gasse, P., C. Mary, I. Guenon, N. Noulin, S. Charron, S. Schnyder-Candrian, B. Schnyder, S. Akira, V. F. Quesniaux, V. Lagente, B. Ryffel, and I. Couillin. 2007.

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest

 

Fremond, C. M., D. Togbe, E. Doz, S. Rose, V. Vasseur, I. Maillet, M. Jacobs, B. Ryffel, and V. F. Quesniaux. 2007.

IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol

 

Doz, E., S. Rose, J. Nigou, M. Gilleron, G. Puzo, F. Erard, B. Ryffel, and V. F. Quesniaux. 2007.

Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan. J Biol Chem

 

Togbe, D., S. Schnyder-Candrian, B. Schnyder, I. Couillin, I. Maillet, F. Bihl, D. Malo, B. Ryffel, and V. F. Quesniaux. 2006.

TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. J Leukoc Biol

 

Togbe, D., G. Aurore, N. Noulin, V. F. Quesniaux, S. Schnyder-Candrian, B. Schnyder, V. Vasseur, S. Akira, K. Hoebe, B. Beutler, B. Ryffel, and I. Couillin. 2006.

Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Lab Invest

 

Savoy, F., D. M. Nicolle, D. Rivier, C. Chiavaroli, B. Ryffel, and V. F. Quesniaux. 2006.

Synthetic triacylated lipid A derivative activates antigen presenting cells via the TLR4 pathway and promotes antigen-specific responses in vivo. Immunobiology

 

Ryffel, B., M. Jacobs, S. Parida, T. Botha, D. Togbe, and V. Quesniaux. 2006.

Toll-like receptors and control of mycobacterial infection in mice. Novartis Found Symp

 

Laumonnier, F., S. Roger, P. Guérin, F. Molinari, R. M’Rad, D. Cahard, A. Belhadj, M. Halayem, A. M. Persico, M. Elia, V. Romano, S. Holbert, C. Andres, H. Chaabouni, L. Colleaux, J. Constant, J. Y. Le Guennec, and S. Briault. 2006.

Association of a functional deficit of the BKCa channel, a synaptic regulator of neuronal excitability, with autism and mental retardation. The American journal of psychiatry

 

Lacoste, C., V. Barthaux, C. Iborra, M. Seagar, and M. Erard-Garcia. 2006.

MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans. Developmental biology

 

Weston-Davies, W., I. Couillin, S. Schnyder, B. Schnyder, R. Moser, O. Lissina, G. C. Paesen, P. Nuttall, and B. Ryffel. 2005.

Arthropod-derived protein EV131 inhibits histamine action and allergic asthma. Ann N Y Acad Sci

 

Weber, M. A., S. Schnyder-Candrian, B. Schnyder, V. Quesniaux, V. Poli, C. L. Stewart, and B. Ryffel. 2005.

Endogenous leukemia inhibitory factor attenuates endotoxin response. Lab Invest

 

Ryffel, B., C. Fremond, M. Jacobs, S. Parida, T. Botha, B. Schnyder, and V. Quesniaux. 2005.

Innate immunity to mycobacterial infection in mice: critical role for toll-like receptors. Tuberculosis (Edinb)

 

Quesniaux, V., and B. Ryffel. 2005.

[Fatal tuberculosis despite adaptive immune response in the absence of MyD88]. Med Sci (Paris)

 

Noulin, N., V. F. Quesniaux, S. Schnyder-Candrian, B. Schnyder, I. Maillet, T. Robert, B. B. Vargaftig, B. Ryffel, and I. Couillin. 2005.

Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J Immunol

 

Laumonnier, F., S. Holbert, N. Ronce, F. Faravelli, S. Lenzner, C. E. Schwartz, J. Lespinasse, H. Van Esch, D. Lacombe, C. Goizet, F. Phan-Dinh Tuy, H. van Bokhoven, J. P. Fryns, J. Chelly, H. H. Ropers, C. Moraine, B. C. Hamel, and S. Briault. 2005.

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate. Journal of medical genetics

 

Fremond, C., N. Allie, I. Dambuza, S. I. Grivennikov, V. Yeremeev, V. F. Quesniaux, M. Jacobs, and B. Ryffel. 2005.

Membrane TNF confers protection to acute mycobacterial infection. Respir Res

 

Brown, N., M. Jacobs, S. K. Parida, T. Botha, A. Santos, L. Fick, B. Gicquel, M. Jackson, V. Quesniaux, and B. Ryffel. 2005.

Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection. Infect Immun

 

Quesniaux, V. J., D. M. Nicolle, D. Torres, L. Kremer, Y. Guérardel, J. Nigou, G. Puzo, F. Erard, and B. Ryffel. 2004.

Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J Immunol

 

Quesniaux, V., C. Fremond, M. Jacobs, S. Parida, D. Nicolle, V. Yeremeev, F. Bihl, F. Erard, T. Botha, M. Drennan, M. N. Soler, M. Le Bert, B. Schnyder, and B. Ryffel. 2004.

Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect

 

Nicolle, D. M., X. Pichon, A. Bouchot, I. Maillet, F. Erard, S. Akira, B. Ryffel, and V. F. Quesniaux. 2004.

Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice. Lab Invest

 

Nicolle, D., C. Fremond, X. Pichon, A. Bouchot, I. Maillet, B. Ryffel, and V. J. Quesniaux. 2004.

Long-term control of Mycobacterium bovis BCG infection in the absence of Toll-like receptors (TLRs): investigation of TLR2-, TLR6-, or TLR2-TLR4-deficient mice. Infect Immun

 

Laumonnier, F., F. Bonnet-Brilhault, M. Gomot, R. Blanc, A. David, M. P. Moizard, M. Raynaud, N. Ronce, E. Lemonnier, P. Calvas, B. Laudier, J. Chelly, J. P. Fryns, H. H. Ropers, B. C. Hamel, C. Andres, C. Barthélémy, C. Moraine, and S. Briault. 2004.

X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. American journal of human genetics

 

Fremond, C. M., V. Yeremeev, D. M. Nicolle, M. Jacobs, V. F. Quesniaux, and B. Ryffel. 2004.

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. J Clin Invest

 

Drennan, M. B., D. Nicolle, V. J. Quesniaux, M. Jacobs, N. Allie, J. Mpagi, C. Frémond, H. Wagner, C. Kirschning, and B. Ryffel. 2004.

Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection. Am J Pathol

 

Couillin, I., I. Maillet, B. B. Vargaftig, M. Jacobs, G. C. Paesen, P. A. Nuttall, J. Lefort, R. Moser, W. Weston-Davies, and B. Ryffel. 2004.

Arthropod-derived histamine-binding protein prevents murine allergic asthma. J Immunol

 

Raynaud, M., S. Dessay, N. Ronce, J. Opitz, M. Pembrey, C. Romano, C. Moraine, and S. Briault. 2003.

Skewed X chromosome inactivation in carriers is not a constant finding in FG syndrome. European journal of human genetics : EJHG

 

Heumann, D., R. Lauener, and B. Ryffel. 2003.

The dual role of LBP and CD14 in response to Gram-negative bacteria or Gram-negative compounds. J Endotoxin Res

 

Gumede, B., P. Folb, and B. Ryffel. 2003.

Oral artesunate prevents Plasmodium berghei Anka infection in mice. Parasitol Int

 

Fremond, C. M., D. M. Nicolle, D. S. Torres, and V. F. Quesniaux. 2003.

Control of Mycobacterium bovis BCG infection with increased inflammation in TLR4-deficient mice. Microbes Infect

 

Botha, T., and B. Ryffel. 2003.

Reactivation of latent tuberculosis infection in TNF-deficient mice. J Immunol

 

Schuurman, H. J., K. Menninger, M. Audet, A. Kunkler, C. Maurer, C. Vedrine, M. Bernhard, L. Gaschen, V. Brinkmann, and V. Quesniaux. 2002.

Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD. Transplantation

 

Laumonnier, F., N. Ronce, B. C. Hamel, P. Thomas, J. Lespinasse, M. Raynaud, C. Paringaux, H. Van Bokhoven, V. Kalscheuer, J. P. Fryns, J. Chelly, C. Moraine, and S. Briault. 2002.

Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency. American journal of human genetics

 

Jacobs, M., L. Fick, N. Allie, N. Brown, and B. Ryffel. 2002.

Enhanced immune response in Mycobacterium bovis bacille calmette guerin (BCG)-infected IL-10-deficient mice. Clin Chem Lab Med

 

Dessay, S., M. P. Moizard, J. L. Gilardi, J. M. Opitz, H. Middleton-Price, M. Pembrey, C. Moraine, and S. Briault. 2002.

FG syndrome: linkage analysis in two families supporting a new gene localization at Xp22.3 [FGS3]. American journal of medical genetics

 

Botha, T., and B. Ryffel. 2002.

Reactivation of latent tuberculosis by an inhibitor of inducible nitric oxide synthase in an aerosol murine model. Immunology

 

Abel, B., N. Thieblemont, V. J. Quesniaux, N. Brown, J. Mpagi, K. Miyake, F. Bihl, and B. Ryffel. 2002.

Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol

 

Núñez, M. T., A. Osorio, V. Tapia, A. Vergara, and C. V. Mura. 2001.

Iron-induced oxidative stress up-regulates calreticulin levels in intestinal epithelial (Caco-2) cells. Journal of cellular biochemistry

 

Nicolas, L. B., W. Pinoteau, S. Papot, S. Routier, G. Guillaumet, and S. Mortaud. 2001.

Aggressive behavior induced by the steroid sulfatase inhibitor COUMATE and by DHEAS in CBA/H mice. Brain research

 

Moser, R., V. Quesniaux, and B. Ryffel. 2001.

Use of transgenic animals to investigate drug hypersensitivity. Toxicology