CV Riteau
Nicolas Riteau CV
Updated Aug 2023
PERSONAL STATEMENT
I have a PhD in immunology (2008-2011) obtained at the university of Orleans, France. In Isabelle Couillin’s team, I studied the role of endogenous danger signals and their capacity to induce sterile lung inflammation and fibrosis. I performed a five-year post-doctoral experience (2012-2017) at the National Institutes of Health in Alan Sher’s laboratory where I studied CD4+ T follicular helper cells. I was recruited as CNRS scientist in 2018 at the INEM laboratory (https://www.inem.cnrs.fr/). My current focus is on STING signaling and lung fibrosis. I am participating in the creation of a CNRS International Research Laboratory (IRL) in the field of immunology that will be located on Ribeirão Preto/University of São Paulo campus under the direction of José Carlos Alves Filho.
EDUCATION
2008-2011 Immunology and Molecular Embryology laboratory, UMR6218
Ph.D. CNRS and University of Orleans, France
Co-Advisors: Dr. Isabelle Couillin and Pr. Bernhard Ryffel
2006-2008 Genome and Proteome Expression and Regulation
M.S. University of Science, Orleans, France
2003-2006 Cellular Biology and Physiology Department of Chemistry
B.S. University of Science, Orleans, France
PROFESSIONAL Experience
2018(Oct)-present Scientist (CRCN, Chargé de recherche de classe normale), Experimental and Molecular Immunology and Neurogenetics (INEM), UMR7355, CNRS, France
2017-2018(Sep) Research Fellow, Experimental and Molecular Immunology and Neurogenetics (INEM), UMR7355, CNRS, France
Role of self-nucleic acids in sterile pulmonary inflammation
2012-2017(May) Postdoctoral Fellow, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Adjuvants in the development and function of T Follicular Helper cells
2011 (3 months) Visiting Scientist, Laboratory of Immuno-pharmacology headed by Pr. Mauro Martins Teixeira, Belo Horizonte, MG, Brazil
Standardization of human PBMC cultures
2008-2011 Ph.D. Candidate, Immunology and Molecular Embryology, UMR6218, CNRS, France
Innate immunity and inflammasome: role of endogenous danger signals
2010 (2 months) Agency for Science, Technology and Research (A*STAR), Singapore
Study of dendritic cells depletion during lung inflammation and fibrosis induced by bleomycin
2007 (3 months) Department of Medical Biotechnology, Jagiellonian University, Krakow, Poland
Heme-oxygenase-1 (HO-1) human promoter regulation in response to different inducers
Summer 2006 Pharmaceutical company SERVIER, Orleans, France
The use of bactosomes in identification and contribution of liver P450 involved in drug metabolism
Fellowships and Awards
2021 “Bright Spark Award” 6th European Congress of Immunology
2019 Selected to attend the InflamSchool, Ribeirao Preto, Brasil
2019 (Oct) Recipient of the “CÁTEDRAS FRANCO-BRASILEIRAS NA UFMG” award to be hosted as a month visiting professor at the Universidade Federal de Minas Gerais (UFMG), Brasil
2012-2017 NIH Intramural Research Training Award (IRTA) Fellowship
2017 (March) Scholarship to serve as a Conference Assistant at the Keystone Symposium – Type I Interferon: Friend and Foe Alike, Banff, Alberta, Canada
2014 Winner of the Fellows’ Award for Research Excellence (FARE), NIH
2013 Selected to attend the 3rd Network of Immunology Frontier Winter school of Advanced immunology, Osaka, Japan
2008-2011 MRT Grant, CNRS, France
(1-20)
Publications
As of August 2023. H-Index : 18 ; Sum of Times Cited: 2,3K Web of Science
1. de Moura Rodrigues D, Lacerda-Queiroz N, Couillin I and Riteau N. STING Targeting in Lung Diseases. Cells. 2022 Nov 3;11(21):3483. doi: 10.3390/cells11213483
2. Huot-Marchand S, Nascimento M, Culerier E, Bourenane M, Savigny F, Panek C, Serdjebi C, Le Bert M, Quesniaux VFJ, Ryffel B, Broz P, Riteau N, Gombault A, Couillin I. Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3. Front Immunol. 2022 Aug 15;13:918507. doi: 10.3389/fimmu.2022.918507.
3. Couillin I. and Riteau N. STING signaling and sterile inflammation Front Immunol. 2021 Oct 1;12:753789. doi: 10.3389/fimmu.2021.753789.
4. Savigny F., Schricke C., Lacerda-Queiroz N, Meda M., Nascimento M., Huot-Marchand S., Da Gama Monteiro F., Ryffel B., Gombault A., Le Bert M., Couillin I. and Riteau N. Protective role of the nucleic acid sensor STING in pulmonary fibrosis. Front Immunol. 2021 Jan 8;11:588799
5. Nascimento M, Huot-Marchand S, Gombault A, Panek C, Bourinet M, Fanny M, Savigny F, Schneider P, Le Bert M, Ryffel B, Riteau N, Quesniaux VFJ, Couillin I. B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure.Front Immunol. 2020 Jul 29;11:1622.
6. Riteau, N., and Bernaudin, J. F. 2020 In addition to mTOR and JAK/STAT, NLRP3 inflammasome is another key pathway activated in sarcoidosis.The European respiratory journal 55 10.1183
7. Nascimento, M., A. Gombault, N. Lacerda-Queiroz, C. Panek, F. Savigny, M. Sbeity, M. Bourinet, M. Le Bert, N. Riteau, B. Ryffel, V. F. J. Quesniaux, and I. Couillin. 2019. Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. Sci Rep 9: 14848.
8. Amaral, E. P., D. L. Costa, S. Namasivayam, N. Riteau, O. Kamenyeva, L. Mittereder, K. D. Mayer-Barber, B. B. Andrade, and A. Sher. 2019. A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis. J Exp Med 216: 556-570.
9. Fanny, M., M. Nascimento, L. Baron, C. Schricke, I. Maillet, M. Akbal, N. Riteau, M. Le Bert, V. Quesniaux, B. Ryffel, A. Gombault, S. Meme, W. Meme, and I. Couillin. 2018. The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin. Front Immunol 9: 1476.
10. Fang, D., K. Cui, K. Mao, G. Hu, R. Li, M. Zheng, N. Riteau, S. L. Reiner, A. Sher, K. Zhao, and J. Zhu. 2018. Transient T-bet expression functionally specifies a distinct T follicular helper subset. J Exp Med 215: 2705-2714.
11. Amaral, E. P., N. Riteau, M. Moayeri, N. Maier, K. D. Mayer-Barber, R. M. Pereira, S. L. Lage, A. Kubler, W. R. Bishai, M. R. D’Imperio-Lima, A. Sher, and B. B. Andrade. 2018. Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages. Front Immunol 9: 1427
12. Riteau, N.*, Radtke, A. J*., Anderson, C. F*., Rausch, K., Scaria, P., Kelnhofer, E. R., Howard, R. F., Sher, A., Germain, R. N., and Duffy, P. (2017) Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate. Sci Rep 7, 40312
13. Lacerda-Queiroz, N., Riteau, N., Eastman, R. T., Bock, K. W., Orandle, M. S., Moore, I. N., Sher, A., Long, C. A., Jankovic, D., and Su, X. Z. (2017) Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model. Sci Rep 7, 10438
14. Riteau, N., and Sher, A. (2016) Chitosan: An Adjuvant with an Unanticipated STING. Immunity 44, 522-524
15. Riteau, N., Radtke, A. J., Shenderov, K., Mittereder, L., Oland, S. D., Hieny, S., Jankovic, D., and Sher, A. (2016) Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway. Journal of immunology 197, 3884-3893
16. Riteau, N., Gombault, A., and Couillin, I. (2016) Assessment of Inflammasome Activation by Cytokine and Danger Signal Detection. Methods Mol Biol 1417, 63-74
17. Charmoy, M., Hurrell, B. P., Romano, A., Lee, S. H., Ribeiro-Gomes, F., Riteau, N., Mayer-Barber, K., Tacchini-Cottier, F., and Sacks, D. L. (2016) The Nlrp3 inflammasome, IL-1beta, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice. Eur J Immunol 46, 897-911
18. Baron, L., Gombault, A., Fanny, M., Villeret, B., Savigny, F., Guillou, N., Panek, C., Le Bert, M., Lagente, V., Rassendren, F., Riteau, N., and Couillin, I. (2015) The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell death & disease 6, e1629
19. Andrade, B. B., Pavan Kumar, N., Amaral, E. P., Riteau, N., Mayer-Barber, K. D., Tosh, K. W., Maier, N., Conceicao, E. L., Kubler, A., Sridhar, R., Banurekha, V. V., Jawahar, M. S., Barbosa, T., Manganiello, V. C., Moss, J., Fontana, J. R., Marciano, B. E., Sampaio, E. P., Olivier, K. N., Holland, S. M., Jackson, S. H., Moayeri, M., Leppla, S., Sereti, I., Barber, D. L., Nutman, T. B., Babu, S., and Sher, A. (2015) Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. Journal of immunology 195, 2763-2773
20. Riteau, N.*, Shenderov, K.*, Yip, R., Mayer-Barber, K. D., Oland, S., Hieny, S., Fitzgerald, P., Oberst, A., Dillon, C. P., Green, D. R., Cerundolo, V., and Sher, A. (2014) Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1beta in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. Journal of immunology 192, 2029-2033
21. Cardone, M., Dzutsev, A. K., Li, H., Riteau, N., Gerosa, F., Shenderov, K., Winkler-Pickett, R., Provezza, L., Riboldi, E., Leighty, R. M., Orr, S. J., Steinhagen, F., Wewers, M. D., Sher, A., Anderson, S. K., Goldszmid, R., McVicar, D. W., Lyakh, L., and Trinchieri, G. (2014) Interleukin-1 and interferon-gamma orchestrate beta-glucan-activated human dendritic cell programming via IkappaB-zeta modulation. PloS one 9, e114516
22. Riteau, N.*, Baron, L.*, Villeret, B., Guillou, N., Savigny, F., Ryffel, B., Rassendren, F., Le Bert, M., Gombault, A., and Couillin, I. (2012) ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation. Cell death & disease 3, e403
23. Gasse, P., Riteau, N., Vacher, R., Michel, M. L., Fautrel, A., di Padova, F., Fick, L., Charron, S., Lagente, V., Eberl, G., Le Bert, M., Quesniaux, V. F., Huaux, F., Leite-de-Moraes, M., Ryffel, B., and Couillin, I. (2011) IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PloS one 6, e23185
24. Conforti-Andreoni, C., Spreafico, R., Qian, H. L., Riteau, N., Ryffel, B., Ricciardi-Castagnoli, P., and Mortellaro, A. (2011) Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. Journal of immunology 187, 5842-5850
25. Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 19449-19454
26. Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F., Marchand-Adam, S., Crestani, B., Ryffel, B., and Couillin, I. (2010) Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. American journal of respiratory and critical care medicine 182, 774-783
27. Riteau, N.*, Gasse, P.* , Charron, S., Girre, S., Fick, L., Petrilli, V., Tschopp, J., Lagente, V., Quesniaux, V. F., Ryffel, B., and Couillin, I. (2009) Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. American journal of respiratory and critical care medicine 179, 903-913
*: Equal contribution
Meetings and Presentations
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2023 Journées d’Animation Scientifique, FéRI (Fédération de recherche en infectiologie), Tours, France. Oral Presentation, “Chronic ozone induces lung inflammation through
NLRP6-dependent activation of pyroptosis and necroptosis”
2023 Inflamma VIII, Centro de Convenções do Hospital Sírio Libanês, São Paulo, Brazil
Invited speaker, “Protective role of STING in pulmonary fibrosis”
2022 Alan Sher Symposium, Lipsett Auditorium, NIH, Bethesda, USA
Oral Presentation, “Protective role of STING in pulmonary fibrosis”
2021 European Congress of Immunology (ECI) Oral Presentation (remote) “Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis”
2019 LE STUDIUM WORKSHOP: DNA sensing and STING activation in lung inflammation, Orléans, France
Oral Presentation, “Protective role of the STING signaling pathway in pulmonary fibrosis”
2019 GREMI Meeting: Inflamed Cells: Latest News From Inside – Pasteur Institute, Paris, France
Poster Presentation, “STING signaling pathway regulates idiopathic pulmonary fibrosis”
2018 XLIII Congress of the Brazilian society of immunology, Ouro Preto, MG, Brazil
Poster Presentation, “Protective role of the nucleic acid sensor STING signaling pathway in idiopathic pulmonary fibrosis”
2018 Journées d’Animation Scientifique, FéRI (Fédération de recherche en infectiologie), Tours, France
Oral Presentation, “Protective role of the STING signaling pathway in pulmonary fibrosis”
2017 Journée de la Recherche Respiratoire (J2R), Quebec, Canada
Poster Presentation, “Role of self-nucleic acids as danger signals activating type I/III interferon signaling pathways in cigarette smoke-induced neutrophilic inflammation”
2017 Keystone Symposium: Type I Interferon: Friend and Foe Alike, Banff, Alberta, Canada Opposing roles of type I interferon in the promotion of T follicular -helper versus -regulatory cells by water-in-oil only adjuvants”
2016 Immunology Interest group, Washington, USA
Oral Presentation, “Water-in-oil only adjuvants selectively promote Tfh polarization through a type I interferon and IL-6 dependent pathway”
2016 Keystone Symposium: T Follicular Helper Cells and Germinal Centers, Monterey, CA, USA
Oral Presentation, “Dual roles for Myd88 and type I IFN in adjuvant induced Tfh polarization”
2015 12th World Congress on Inflammation, Boston, MA, USA
Poster Presentation, “Deciphering the signals required for follicular helper T cell generation in the absence of exogenous microbial stimuli”
2015 Immunology Interest group, Washington, USA
Poster Presentation, “Deciphering the signals required for follicular helper T cell generation in the absence of exogenous microbial stimuli”
2013 Research Festival, National Institutes of Health, Bethesda, MD, USA
Oral Presentation, “ER stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway”
2013 Immunology Interest group, Washington, USA
Oral Presentation, “ER stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway”
2011 10th World Congress of Inflammation, Paris, France
Oral Presentation, “Purinergic Signaling: a common pathway for crystals-mediated inflammasome activation”
2010 British Thoracic Society Winter Meeting, London, UK
Oral Presentation, “Nanoparticles cause pulmonary inflammation through IL-1a and partial activation of the NLRP3 inflammasome”
2010 13th International Conference on Lymphocyte Activation and Immune Regulation. Newport Beach, CA, USA
Poster Presentation, “Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis
2009 European Congress of Immunology (ECI), Berlin, Germany
Poster Presentation, “Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis”
2008 Journée de la Recherche Respiratoire (J2R), Paris, France
Poster Presentation, “Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis”
Committee
2023- Member of CED65 « Collège des écoles doctorales et HDR », University of Orléans
2022- Board Member of the GREMI (« Recherche sur les médiateurs de l’inflammation »)
2016 – Review Editor in Frontiers in Immunology
2013 – 2016 Assistant Editor, Inflammasome, Versita
2013 – 2016 Laboratory of Parasitic diseases post-doc committee member, NIH, USA
2008 – 2011 Science University Delegate, University of Orleans Advisory Committee
reviewing ACTIVITIES
2012- Reviewer for PLOS-ONE and JOVE
2014- Reviewer for The Journal of Immunology and Respiratory Research
2016- Reviewer for Trends in Immunology
2016- Reviewer for Frontiers in Immunology
2018- Reviewer for Mediators of inflammation
2019- Reviewer for European Respiratory Journal, International Journal of Molecular Sciences, Pharmaceutics, Prostaglandins and other lipid mediators
Teaching and Mentoring Experience
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2020 HDR (“habilitation à diriger des recherches”) delivered by the University of Orléans
2017- PhD Director (2021-2024)
PhD Co-director (2022-2023) Cotutelle EIFFEL
BTS and master 1/2 students
2008-2011 Teaching assistant “moniteur”. Practical courses to Undergraduate Students in Physiology (96 hours/year) and Immunology lectures to B.Sc students, Science University, Orleans, France
2008-2011 One second year BTS, one Master 2 and one PhD students, Immunologie et Embryologie moléculaire, UMR6218, CNRS and University of Orleans, France
Languages
French: Mother tongue
English: Read, written, spoken
Brazilian Portuguese: Read, written, spoken
