{"id":543,"date":"2021-08-30T12:57:01","date_gmt":"2021-08-30T10:57:01","guid":{"rendered":"https:\/\/www.inem.cnrs.fr\/?page_id=543"},"modified":"2026-07-23T17:24:17","modified_gmt":"2026-07-23T15:24:17","slug":"groupe-neurotoxicite-developpement-presentation","status":"publish","type":"page","link":"https:\/\/www.inem.cnrs.fr\/index.php\/groupe-neurotoxicite-developpement-presentation\/","title":{"rendered":"Groupe Neurotoxicit\u00e9 &#038; D\u00e9veloppement-Pr\u00e9sentation"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"543\" class=\"elementor elementor-543\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4b2e0e0f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b2e0e0f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-5b56f8f5\" data-id=\"5b56f8f5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-15cb4e1d elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"15cb4e1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"https:\/\/www.inem.cnrs.fr\/index.php\/equipes-inem\/\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-arrow-left\"><\/i>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-615424f\" data-id=\"615424f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-31035d46 elementor-widget elementor-widget-heading\" data-id=\"31035d46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.inem.cnrs.fr\/index.php\/equipes-inem\/\">RETOUR AUX EQUIPES<\/a><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-648654b2\" data-id=\"648654b2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-126b5e0e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"126b5e0e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-2d1117fa\" data-id=\"2d1117fa\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6ee1a63\" data-id=\"6ee1a63\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c68ba08 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"7c68ba08\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/www.inem.cnrs.fr\/index.php\/groupe-neurotoxicite-developpement-presentation\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-id-card\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Pr\u00e9sentation<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-36ec5f44\" data-id=\"36ec5f44\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d134585 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"7d134585\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md elementor-animation-grow\" href=\"https:\/\/www.inem.cnrs.fr\/index.php\/groupe-neurotoxicite-developpement-membres\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-address-book\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">  Membres<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-3134302f\" data-id=\"3134302f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7ee78be9 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"7ee78be9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md elementor-animation-grow\" href=\"https:\/\/www.inem.cnrs.fr\/index.php\/groupe-neurotoxicite-developpement-projets\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-flask\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Projets<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-464f1176\" data-id=\"464f1176\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-78ee14ed elementor-widget elementor-widget-button\" data-id=\"78ee14ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md elementor-animation-grow\" href=\"https:\/\/www.inem.cnrs.fr\/index.php\/groupe-neurotoxicite-developpement-publications\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-university\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Publications<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-7ee4716f\" data-id=\"7ee4716f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-690ce39b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"690ce39b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-28e6463\" data-id=\"28e6463\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3e1db4fc elementor-widget elementor-widget-spacer\" data-id=\"3e1db4fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f645674 elementor-widget elementor-widget-text-editor\" data-id=\"5f645674\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><span style=\"color: #325ca6; font-size: 40px;\">\u00c9quipe\u00a0<\/span><span style=\"color: #325ca6; font-size: 40px; font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">Polluants de l&rsquo;environnement, Neurotoxicit\u00e9 et Neuro-inflammation<\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-56218cf9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"56218cf9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-330215f7\" data-id=\"330215f7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-30c0263a elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"30c0263a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"238\" height=\"238\" src=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/smortaud.jpg\" class=\"attachment-large size-large wp-image-5562\" alt=\"\" srcset=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/smortaud.jpg 238w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/smortaud-150x150.jpg 150w\" sizes=\"(max-width: 238px) 100vw, 238px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7162a794\" data-id=\"7162a794\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-204064c2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"204064c2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-388836f1\" data-id=\"388836f1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-70460503 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"70460503\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Responsable: St\u00e9phane Mortaud<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb04bc9 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"bb04bc9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>St\u00e9phane Mortaud (Professeur des Universit\u00e9s &#8211; PR1, Universit\u00e9 d&rsquo;Orl\u00e9ans)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7cd87e07 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7cd87e07\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2fb38741\" data-id=\"2fb38741\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dabf819 elementor-widget elementor-widget-heading\" data-id=\"dabf819\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><p class=\"MsoNormal\" style=\"margin-bottom:7.5pt;line-height:normal\"><span lang=\"FR\" style=\"font-size: 31pt;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial\">Pr\u00e9sentation<\/span><span style=\"color: var( --e-global-color-primary );font-family: var( --e-global-typography-primary-font-family ), Sans-serif;font-size: 2.5rem;font-weight: var( --e-global-typography-primary-font-weight )\"><\/span><\/p><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71f11407 elementor-widget elementor-widget-text-editor\" data-id=\"71f11407\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"MsoNormal\" style=\"margin-bottom: 7.5pt; line-height: normal;\"><b><span lang=\"FR\" style=\"font-size: 14.0pt; mso-bidi-font-size: 11.0pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; color: #002060; mso-ansi-language: FR; mso-fareast-language: EN-US;\">La th\u00e9matique g\u00e9n\u00e9rale de l&rsquo;\u00e9quipe porte sur la vuln\u00e9rabilit\u00e9 du syst\u00e8me nerveux aux facteurs environnementaux au cours du d\u00e9veloppement, notamment suite \u00e0 l&rsquo;exposition chronique \u00e0 des polluants environnementaux (pesticides, cyanotoxines, m\u00e9dicaments, etc.) et \u00e0 les p\u00e9riodes de vuln\u00e9rabilit\u00e9s que sont la gestation et le d\u00e9veloppement pr\u00e9coce postnatal. L\u2019objectif est d\u2019\u00e9tudier l\u2019impact sur les interactions g\u00e8nes\/environnement et leurs cons\u00e9quences sur les processus du neuro-d\u00e9veloppement et de la neuro-inflammation, cet impact pouvant \u00eatre \u00e0 l&rsquo;origine de d\u00e9ficiences permanentes \u00e0 cours, moyen ou long terme. Ces principes fondamentaux constituent la base de l&rsquo;hypoth\u00e8se de Barker, connue sous le nom d&rsquo;approche DOHaD (<i>Developmental Origins of Health and Diseases<\/i>). Par ailleurs l\u2019\u00e9quipe s\u2019int\u00e9resse aux effets d\u2019expositions chez l\u2019adulte, et de leurs implications dans l\u2019induction d\u2019une neuro-inflammation et de l\u2019\u00e9tablissement de neuropathies centrales et\/ou p\u00e9riph\u00e9riques<\/span><\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26cbab94 elementor-widget elementor-widget-spacer\" data-id=\"26cbab94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3cb7ecd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3cb7ecd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-388c55b\" data-id=\"388c55b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a2aa442 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"a2aa442\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-1024x1024.jpg\" class=\"attachment-large size-large wp-image-6045\" alt=\"\" srcset=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-1024x1024.jpg 1024w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-300x300.jpg 300w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-150x150.jpg 150w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-768x768.jpg 768w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-1536x1536.jpg 1536w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-2048x2048.jpg 2048w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/2-NSC-1080x1080.jpg 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Cellules Souches Neurales<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-931399c\" data-id=\"931399c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6e3c3af elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"6e3c3af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"866\" height=\"866\" src=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/Inem-illustration-neurotox-nph.jpg\" class=\"attachment-large size-large wp-image-5567\" alt=\"\" srcset=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/Inem-illustration-neurotox-nph.jpg 866w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/Inem-illustration-neurotox-nph-300x300.jpg 300w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/Inem-illustration-neurotox-nph-150x150.jpg 150w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/Inem-illustration-neurotox-nph-768x768.jpg 768w\" sizes=\"(max-width: 866px) 100vw, 866px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Neurosph\u00e8re (culture 3D)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-de12e84 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"de12e84\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70fdc0b\" data-id=\"70fdc0b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a1fe013 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a1fe013\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eeb53dd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eeb53dd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-371fec4\" data-id=\"371fec4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1d094b5 elementor-widget elementor-widget-heading\" data-id=\"1d094b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Mars 2023<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9aa22ce elementor-widget elementor-widget-image\" data-id=\"9aa22ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"499\" src=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2023\/03\/Graphical_abstract_vf-Sarah-Meresse-paper-2023.jpg\" class=\"attachment-large size-large wp-image-3871\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4925e5f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4925e5f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-62daacf\" data-id=\"62daacf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-04bb29a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"04bb29a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2a85753\" data-id=\"2a85753\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5479cd elementor-widget elementor-widget-text-editor\" data-id=\"b5479cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Cette \u00e9tude a \u00e9t\u00e9 r\u00e9alis\u00e9e en collaboration avec le Laboratoire BiOSSE du Mans. Nous avons \u00e9tudi\u00e9 les effets d&rsquo;un pigment issu d&rsquo;une diatom\u00e9e (microalgue), appel\u00e9 marennine, sur les ph\u00e9nom\u00e8nes neuro-inflammatoires et sur la migration cellulaire. Les r\u00e9sultats indiquent que la marennine interagit fortement avec les processus neuro-inflammatoires au sein des cellules immunocomp\u00e9tentes du syst\u00e8me nerveux central, repr\u00e9sent\u00e9es par les astrocytes et les cellules microgliales. Une activit\u00e9 anti-migratoire bas\u00e9e sur un test de migration des neurosph\u00e8res a \u00e9galement \u00e9t\u00e9 observ\u00e9e.<\/p><p><u>Lien original de la publication:<\/u><\/p><p>Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model. <b>Sarah M\u00e9resse<\/b>, H\u00e9l\u00e8ne Gateau, Tessa Tirnan, <b>Vanessa Larrigaldie<\/b>, Nathalie Casse, Pamela Pasetto, Jean-Luc Mouget, <b>St\u00e9phane Mortaud <\/b>and Mostefa Fodil <em>Int. J. Mol. Sci.<\/em>\u00a02023,\u00a0<em>24<\/em>(6), 5388;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/ijms24065388\" target=\"_blank\" rel=\"noopener\"><strong>https:\/\/doi.org\/10.3390\/ijms24065388<\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fc54ebb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fc54ebb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-14705ac\" data-id=\"14705ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2964ff4 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"2964ff4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"780\" src=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/RGB-microglie-1024x780.jpg\" class=\"attachment-large size-large wp-image-6064\" alt=\"\" srcset=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/RGB-microglie-1024x780.jpg 1024w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/RGB-microglie-300x229.jpg 300w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/RGB-microglie-768x585.jpg 768w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/09\/RGB-microglie.jpg 1344w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Cellules microgliales. Immunocytologie : Iba1 (vert), DAPI (gris) Sarah M\u00e9resse, 2023 \/ INEM<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7ae8e04\" data-id=\"7ae8e04\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4368ae8 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"4368ae8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/12\/orga2-j42-sox2-488-MAP2-594-DAPI-x40-2-merged-1024x1024.jpg\" class=\"attachment-large size-large wp-image-6160\" alt=\"\" srcset=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/12\/orga2-j42-sox2-488-MAP2-594-DAPI-x40-2-merged-1024x1024.jpg 1024w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/12\/orga2-j42-sox2-488-MAP2-594-DAPI-x40-2-merged-300x300.jpg 300w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/12\/orga2-j42-sox2-488-MAP2-594-DAPI-x40-2-merged-150x150.jpg 150w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/12\/orga2-j42-sox2-488-MAP2-594-DAPI-x40-2-merged-768x768.jpg 768w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/12\/orga2-j42-sox2-488-MAP2-594-DAPI-x40-2-merged-1080x1080.jpg 1080w, https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/2025\/12\/orga2-j42-sox2-488-MAP2-594-DAPI-x40-2-merged.jpg 1382w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Organoide c\u00e9r\u00e9bral humain \u00e0 partir d'IPSC. Immunocytologie : MAP2 (rouge), SOX2 (vert), DAPI (bleu) Aurora Devillaz, 2025 \/ INEM<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9ab0579 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9ab0579\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c5eeb44\" data-id=\"c5eeb44\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3bb04d6 elementor-widget elementor-widget-image\" data-id=\"3bb04d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/doi.org\/10.13140\/RG.2.2.34445.29924\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.inem.cnrs.fr\/wp-content\/uploads\/elementor\/thumbs\/screen-rqu2uqwg1h8w3mzcmfy4g5837g37jrpqss3n6z7tdc.png\" title=\"screen\" alt=\"screen\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">BD NeuroTEM<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d72ff03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d72ff03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5103f8f\" data-id=\"5103f8f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a2bf5df elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a2bf5df\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eeb2c09\" data-id=\"eeb2c09\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>RETOUR AUX EQUIPES Pr\u00e9sentation Membres Projets Publications \u00c9quipe\u00a0Polluants de l&rsquo;environnement, Neurotoxicit\u00e9 et Neuro-inflammation Responsable: St\u00e9phane Mortaud St\u00e9phane Mortaud (Professeur des Universit\u00e9s &#8211; PR1, Universit\u00e9 d&rsquo;Orl\u00e9ans) Pr\u00e9sentation La th\u00e9matique g\u00e9n\u00e9rale de l&rsquo;\u00e9quipe porte sur la vuln\u00e9rabilit\u00e9 du syst\u00e8me nerveux aux facteurs environnementaux au cours du d\u00e9veloppement, notamment suite \u00e0 l&rsquo;exposition chronique \u00e0 des polluants environnementaux (pesticides,&hellip; <br \/> <a class=\"read-more\" href=\"https:\/\/www.inem.cnrs.fr\/index.php\/groupe-neurotoxicite-developpement-presentation\/\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-543","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages\/543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/comments?post=543"}],"version-history":[{"count":128,"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages\/543\/revisions"}],"predecessor-version":[{"id":6438,"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages\/543\/revisions\/6438"}],"wp:attachment":[{"href":"https:\/\/www.inem.cnrs.fr\/index.php\/wp-json\/wp\/v2\/media?parent=543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}